Endocrine Abstracts

Background: HLA-DRB1*04 is one of the MHC alleles which is associated with several autoimmune endocrinopathies, including autoimmune Addison’s disease (AAD). The two versions of the gene which encodes the main target of the autoimmune attack in AAD, steroid 21-hydroxylase, are encoded in a gene cluster, called RCCX module, which is a copy number variation located in the MHC class III locus. Previous data from our group showed that AAD patients are more likely to have no c...

Dysbiosis of the gut microbiome contributes to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Reduced diversity and composition of the microbiome are associated with increased intestinal barrier permeability, increased bacterial translocation and NAFLD progression. The ALIOS diet in rodents replicates many of the metabolic and histological features of NAFLD in humans and here we report the effect of the ALIOS diet on the gut microbiome. Male and female C57BL/6 ...

Objective: Exogenous estradiol increases cortisol binding globulin (CBG) and total cortisol (TC), and therefore it is debated if estradiol supplementation should be paused before evaluation of the adrenal axis. The aim was to evaluate how oral and transdermal estradiol influence TC in hypogonadal women with, or at risk of developing, adrenal insufficiency (AI)Methods: This was a crossover study in 17 women with secondary hypogonadism who were tested with...

A 35-year-old gentleman was referred to our Endocrinology department by Moorfields Eye hospital. He reported a one-year history of visual decline in his right eye, which led to prescription glasses, and incidental finding of bilateral conjunctival nodules. He had reduced visual acuity (pinhole right eye: 6/24 and left eye 6/6) and prominent corneal nerves on slit-lamp examination. He underwent an excisional biopsy of the conjunctival nodules confirming bilateral conjunctival n...

Objective: The SH2B3 gene encodes the src homology-2B adaptor protein 3, also known as lymphocyte adaptor protein (LNK), and is a negative regulator of T lymphocyte activation and the cytokine signalling pathways involved in inflammation and haematopoiesis. rs3184504, a non-synonymous SNP (R262W) in exon 3 of the SH2B3 gene, has been associated with numerous autoimmune conditions including type 1 diabetes, rheumatoid arthritis and coeliac disease. Th...

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, ranging from simple steatosis to the necro-inflammatory disease, non-alcoholic steatohepatitis (NASH). Development of NASH subsequently increases risk of hepatocellular carcinomas (HCC). Alongside the impact on the liver, NASH is associated with other clinical features, including insulin resistance, hyperlipidaemia and sarcopaenia. We demonstrate that mice fed the American lifestyle i...

Introduction: Intermediate cytology comprises unclear result form Bethesda III and IV category. This category is still present in the general results of thyroid cytology, with 2–18% AUS/FLUS and 2–5% FN. The attitude after such a results is not standardize, follow up, lobectomy or thyroidectomy being the possible indications to solve such a case. The current paper presents the value of predictive value of ultrasound techniques in the final judgment of these cases.</p...

Background: Sheehan’s syndrome occurs after a delivery complicated with hemorrhage causing ischemic pituitary necrosis and panhypopituitarism. It is rare for a patient with Sheehan’s syndrome to obtain recovery of the pituitary function. We report the case of a patient with Sheehan’s syndrome who obtained a spontaneous pregnancy 2 years after the initial diagnosis.Case presentation: A 23-year-old-woman, without a significant personal medic...

Introduction: Primary adrenal lymphoma is extremely rare. It accounts for <1% of extranodal lymphoma. It affects typically old males with bilateral adrenal gland involvement that leads to adrenal hypofunction. Prognosis is very poor due to the lack of optimum chemotherapeutic regimens.Case Report: A 71 yearr old man with prior history of non insulin dependent diabetes, was admitted to the emergency department with symptoms of progressive weakness, fa...

Background: Empty sella (ES) is often an incidental imaging finding, associated or not with the following symptoms: headache, hypopituitarism or visual impairment. Two etiological forms are described: primary ES due to a combination of increased spinal fluid pressure and a defect in the sella diaphragm and secondary ES due to the shrinkage of the pituitary gland (after pituitary surgery, radiation, apoplexy, hypophysitis or neurosarcoidosis).Clinical cas...